I guess this one’s been simmering for awhile… but Katherine Heigl and T.R. Knight have now officially quit Grey’s Anatomy.

Grey’s Anatomy co-star James Pickens Jr. confirmed both actors are leaving the series, saying, “Yes, she [Kathering Heigl] is. Wherever Katherine goes, I wish her nothing but the best.” and “He’s [T.R. Knight] going too. He just wanted to pursue other career paths.”

So now comes the question of how they’ll wrap up each character’s storyline.

Any predictions about what will happen with Izzie and George?