Katherine Heigl shouldn’t bite the hand that feeds her, so to speak. Katherine Heigl, who plays Izzie on “Grey’s Anatomy,” says of her hookup with George (T.R. Knight), “It was a ratings ploy. I’m trying to figure her out and keep her real.”

Katherine Heigl also commented in the January issue of Vanity Fair that the hit film “Knocked Up” is “a little sexist,” saying, “It paints the women as shrews, as humorless and uptight, and it paints the men as goofy, fun-loving guys. It was hard for me to love the movie.”